Mood Change Medicine
BDNF (brain-derived neurotrophic factor)
Do Tart Cherries Improve Sleep?
Sweet and tart cherries improved both sleep quality and quantity, some studies show. With effects rivaling melatonin and valerian, tart cherry extended total sleep time by a whopping 84-minutes, a result that is better than most sleeping pills, one small study showed. All that and superb health benefits! Continue reading
St. John’s Wort: Getting its Benefits without the Drawbacks
St. John’s wort may fight depression by modulating cortisol, calming stress, extinguishing inflammation, boosting neurogenesis and neuroplasticity, increasing tryptophan and normalizing melatonin. But there are more powerful ways to heal depression that do all those things and more. Continue reading
5-HTP: Are antidepressants effective, and if so why?
5-HTP might be as effective as SSRI antidepressants like Prozac. But that might not be saying much. Most (if not all) of the benefits of SSRIs “are due to the placebo effect,” a re-analysis of FDA studies found. Antidepressants and 5-HTP may work in ways that don’t involve boosting serotonin. Continue reading
Low Tryptophan = Low Serotonin. Does Low Serotonin = Depression?
There’s a major controversy over whether or not depression is caused by low tryptophan and it’s consequence—low serotonin. Some researchers assert that there’s no support for the hypothesis that depression is caused by lowered serotonin. What does the science say about the causes of depression . . . Continue reading
Exercise Better than Drugs for Lifting Mood
The most common antidepressant drugs got bottom-of-the barrel results in a landmark systematic review comparing the drugs’ effect on depression with that of the talk-therapy CBT and a range of exercise modalities, according to data published by the prestigious British Medical Journal in February 2024. Continue reading
Foods that Stress and Depress—Foods that Promote Well-being
A 2017 randomized controlled trial of 67 depressed patients asked the question: “If I improve my diet, will my mental health improve?” Half of them received nutrition counseling, and for them the answer was yes. Not true for the other half, who got social support sessions instead of nutrition counseling. Continue reading
Gut-Brain Axis: Director of Mental Health?
There’s burgeoning evidence that the various bacterial species inhabiting our gut have an important influence on our psychological health. Based on their antidepressant and anxiolytic effects, these beneficial bacteria that inhabit our GI tract have been dubbed “psychobiotics”. Continue reading
Mindfulness-Based Cognitive Therapy: A Swiss-Army Knife for Tackling Anxiety & Depression
The value of reducing stress is widely embraced. An analytic review of 39 studies including 1,140 people with conditions including generalized anxiety disorder and depression found that mindfulness-based therapy, a widely-used stress-busting technique, was associated with significant improvement in anxiety disorders and depression. Continue reading
Escaping the Vicious Cycle of Stress
Chronic stress causes Inflammation and can be very damaging to mental and physical health. Stress does damage through repeated activation of the fight-or-flight mechanisms of the body. This causes a cascade of biochemical events leading to hyperactivation of inflammatory proteins linked to depression, anxiety and a host of other conditions. Continue reading
Inflammation: Foe of Mental Health
Depressed patients starting psychotherapy with higher levels of inflammation are less likely to be helped by it, a 2020 study showed. And for those who had somatic symptoms of depression—like appetite changes, fatigue, aches and pains and sleep disturbances—the worse the symptoms, the higher the levels of inflammation. Continue reading
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