Mood Change Medicine
Herbal Supplements
5-HTP: Are antidepressants effective, and if so why?
5-HTP might be as effective as SSRI antidepressants like Prozac. But that might not be saying much. Most (if not all) of the benefits of SSRIs “are due to the placebo effect,” a re-analysis of FDA studies found. Antidepressants and 5-HTP may work in ways that don’t involve boosting serotonin. Continue reading
How safe are 5-HTP supplements?
A task force composed of 31 leading academics and clinicians from 15 countries concluded—based on Grade A level evidence—that 5-HTP has “Acceptable safety data”. Case reports of serious side effects following excessive doses or combinations of certain medications with 5-HTP raises the possibility of risk. . . . Continue reading
5-HTP: Efficacy for Depression, Anxiety & Insomnia
5-HTP might be as effective for depression as Prozac, but the evidence of efficacy is unclear for both the supplement and the antidepressant pharmaceuticals. It’s possible 5-HTP might help some people with either insomnia or anxiety. But the evidence is less clear. . . . Continue reading
Tryptophan: Interactions with Drugs & Supplements
Tryptophan can interact with drugs and supplements that cause sedation, increasing the sedative effect. Taking tryptophan with any of these drugs, substances or supplements might cause excessive sleepiness and negatively impact the ability to drive or operate heavy machinery. Continue reading
Are Tryptophan Supplements Effective for Anxiety & Depression?
Tryptophan deficiency has been linked to depression in some people. Not all tryptophan deficiencies are the result of inadequate intake. A deficiency can be caused by problems like absorption issues. Other treatments that are more effective for anxiety and depression include talk therapy, biofeedback, mindfulness and other supplements like . . . Continue reading
Bewildering Array of CBD Products
Different formulations taken at different doses can have very different effects in the body. Full-spectrum CBD products contain all the naturally-occurring compounds found in the cannabis plant, including THC. “Broad spectrum” or “wide spectrum” CBD products may also contain these components but without the THC. Continue reading
CBD: Is there a sweet spot for dosing?
Researchers found a sweet spot for dosing—higher or lower doses aren’t as effective as those in the middle of the dosage range. But this may not hold true for full-spectrum products that contain both CBD, THC and other constituents in the cannabis plant. Continue reading
Is CBD Addictive?
Because CBD was not found be mind-altering or to present potential for abuse or dependence, a World Health Organization Committee on Drug Dependence recommended that CBD be removed from international drug control. Continue reading
CBD: Precautions & Drug Interactions
Pure CBD appears to have a better safety profile than that of THC-CBD mixtures with high THC content. CBD may interact with numerous medications including enhancing their sedating effects. In animals, high doses of CBD have caused negative effects on developing fetuses, including on the reproductive organs of male children. Continue reading
Cannabinoid Side Effects & Drug Interactions
Expert panel asserts serious side effects of cannabinoids are rare but can include: acute coronary syndrome, arrhythmias, myocarditis, blood pressure changes, hallucinations, pancreatitis, panic, psychosis, seizures, and cannabinoid hyperemesis syndrome (CHS) leading to uncontrollable vomiting. There’s limited information on side effects of pure THC. Continue reading
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