St. John’s wort may fight depression by modulating cortisol, calming stress, extinguishing inflammation, boosting neurogenesis and neuroplasticity, increasing tryptophan and normalizing melatonin. But there are more powerful ways to heal depression that do all those things and more. Continue reading
There’s a major controversy over whether or not depression is caused by low tryptophan and it’s consequence—low serotonin. Some researchers assert that there’s no support for the hypothesis that depression is caused by lowered serotonin. What does the science say about the causes of depression . . . Continue reading
Melatonin is a sleep-promoting hormone that is naturally produced and secreted by the pineal gland in the brain. The impact of naturally-occurring melatonin on our bodies is broad, profound, and not completely understood. Continue reading
The most common antidepressant drugs got bottom-of-the barrel results in a landmark systematic review comparing the drugs’ effect on depression with that of the talk-therapy CBT and a range of exercise modalities, according to data published by the prestigious British Medical Journal in February 2024. Continue reading
Depressed patients starting psychotherapy with higher levels of inflammation are less likely to be helped by it, a 2020 study showed. And for those who had somatic symptoms of depression—like appetite changes, fatigue, aches and pains and sleep disturbances—the worse the symptoms, the higher the levels of inflammation. Continue reading
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